Manchester United's Mourinho has not lost a game against Arsenal's Arsene Wenger in any of the 13 league and cup matches where they have faced each other. Wenger's only victory over the Special One came in the 2015 Community Shield.
The Red Devils have not lost at Old Trafford since their 2-1 defeat to rivals Manchester City and Saturday's game starts a run of four games at the Theatre of Dreams.
Zlatan Ibrahimovich picked up his fifth yellow card last game against Swansea and will watch the game from the stands as he serves his one-match ban. Wayne Rooney was withdrawn from the England squad this week and it remains to be seen whether he will take part against the Gunners, meaning Marcus Rashford or Anthony Martial are expected to spearhead the attack.
Arsenal have not lost since the first game of the season against Liverpool, a game which saw many of the first-team sit out through injury. With a full strength-squad, Arsenal have performed admirably, but as is tradition, some key players have picked up injuries in November.
Alexis Sanchez suffered a muscle injury in training with Chile, but bounced back to score twice to give Chile a 3-1 victory over Uruguay late on Tuesday night. An early Saturday kick-off is far from ideal for Sanchez, but Wenger cannot afford to rest his talisman with the top of the table looking so tight at the moment.
Meanwhile, Hector Bellerin will be out for a month with an ankle injury. This will seriously weaken Arsenal's right-flank and Walcott's impact could be dented as he will have to track back more to help out and will get fewer supporting runs from whoever starts at right-back.
Who to Draft First?
Arsenal's top three players in their past three league games by points:
Ozil: 55(MID), 124(SUN), 81(TOT)
Sanchez: 63 (MID), 163 (SUN), 61 (TOT)
Koscielny: 90 (MID), 81 (SUN), 52 (TOT)
Manchester United's top three players in their past three league games:
Pogba: 97 (CHE), 184(BRN), 173(SWA)
Ibrahimovic: 76(CHE), 139(BRN), 145(SWA)
Mata: 58(CHE), 172(CHE), 84(SWA)
One to Watch
Marcus Rashford will likely be deployed upfront for Man United in Ibrahimovich's absence and will not be wasted on the wings.
The young forward has three Premier League goals to his name so far and will be looking to impress in the Swede's absence.